Verstraelen Hans, Vanzieleghem Bart, Defoort Paul, Vanhaesebrouck Piet, Temmerman Marleen
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Prenat Diagn. 2003 Sep;23(9):705-9. doi: 10.1002/pd.669.
To assess the diagnostic value of prenatal magnetic resonance imaging (MRI) in addition to prenatal ultrasound in a case of fetal varicella syndrome.
Comparison of prenatal ultrasound and MRI features obtained at 26 and 32 weeks, respectively, with neonatal imaging (ultrasound, MRI and CT) and macroscopic and microscopic pathology findings in a fatal case of varicella embryopathy.
Prenatal ultrasound correlated fairly well with neonatal imaging and pathology findings. Most lesions of thoracic, abdominal and retroperitoneal viscera, limb involvement and even dermatologic features were apparent on ultrasonography. Involvement of the CNS, including cerebellar hypoplasia, was not apparent on ultrasound examination, but was clearly demonstrated by prenatal MRI.
If maternal seroconversion for the varicella-zoster virus is suspected, combining prenatal ultrasound and magnetic resonance imaging may document the extent of tissue damage in fetal varicella syndrome to a larger extent than has been reported until now and therefore contribute to due counselling following maternal varicella exposure.
评估在胎儿水痘综合征病例中，产前磁共振成像（MRI）联合产前超声检查的诊断价值。
对分别在孕26周和32周获得的产前超声和MRI特征，与1例水痘胚胎病致死病例的新生儿影像学检查（超声、MRI和CT）以及大体和显微镜下病理结果进行比较。
产前超声与新生儿影像学检查及病理结果相关性良好。超声检查可清晰显示胸、腹及腹膜后脏器的多数病变、肢体受累情况甚至皮肤特征。中枢神经系统受累，包括小脑发育不全，超声检查未显示，但产前MRI可清晰显示。
如果怀疑孕妇水痘 - 带状疱疹病毒血清学转换，联合应用产前超声和磁共振成像可能比目前报道的能更全面地记录胎儿水痘综合征的组织损伤程度，从而有助于在孕妇感染水痘后提供适当的咨询。
