Gonzalez C
J Fr Ophtalmol. 1992;15(10):529-36.
The effect of acetazolamide in the treatment of chronic macular edema has been well established. The pharmacologic action of this product suggested possible efficacy in the treatment of serous retinal detachment. We studied 38 patients presenting with serous retinal detachments of various etiologies divided into four groups: age related macular degeneration, central serous chorioretinopathy or diffuse epithelial retinopathy, epiretinal membranes, and other causes. Treatment with acetazolamide, at a dosage of 0.375 g/day, in three divided doses was proposed for five weeks. We observed a reduction of metamorphopsia in all cases, a stability or even an improvement of visual acuity, and a resorption of serous retinal detachment confirmed by decreased pooling of fluorescein on the angiographic examination. Considering each etiology, clinical and angiographic findings demonstrated the value of this treatment, although this study was not prospective. The encouraging results observed in many cases, raise hopes concerning the treatment for these diseases, usually not amenable to treatment.
乙酰唑胺治疗慢性黄斑水肿的效果已得到充分证实。该产品的药理作用提示其在治疗浆液性视网膜脱离方面可能有效。我们研究了38例患有各种病因浆液性视网膜脱离的患者，分为四组：年龄相关性黄斑变性、中心性浆液性脉络膜视网膜病变或弥漫性上皮性视网膜病变、视网膜前膜以及其他病因。建议给予乙酰唑胺治疗，剂量为0.375克/天，分三次服用，持续五周。我们观察到所有病例的视物变形均减轻，视力稳定甚至有所提高，并且通过血管造影检查发现荧光素渗漏减少证实了浆液性视网膜脱离的吸收。考虑到每种病因，临床和血管造影结果均证明了这种治疗方法的价值，尽管本研究并非前瞻性研究。在许多病例中观察到的令人鼓舞的结果，为这些通常难以治疗的疾病的治疗带来了希望。
