Kern P, Dietrich M, Volkmer K J
Tropenmed Parasitol. 1979 Mar;30(1):65-72.
The effect of high dosage therapy with Mebendazole was studied in 5 patients with cystic echinococcosis and 2 patients with alveolar echinococcosis involving several organs. Follow-up studies at regular intervals from 7 to 20 months indicated an improvement of the pathological findings initially observed. This could clearly be demonstrated by the radiographic findings in cases with pulmonary involvement. The desintegration or dissolution of pulmonary cysts was observed within a few months after treatment with Mebendazole had begun. However, consolidation of previously emptied cysts occurred during the follow-up later. Allergic reactions were observed after commencement of drug therapy in two cases. These were probably due to spillage of antigenic material. The following treatment periods were tolerated well. No serious toxic side effects were observed in the other cases described here.
对5例囊性棘球蚴病患者和2例累及多个器官的泡状棘球蚴病患者进行了甲苯达唑高剂量疗法的疗效研究。在7至20个月的定期随访研究表明，最初观察到的病理结果有所改善。这在肺部受累病例的影像学检查结果中得到了明确证实。在用甲苯达唑治疗开始后的几个月内，观察到肺囊肿的崩解或溶解。然而，在随后的随访中，先前排空的囊肿出现了实变。在两例患者药物治疗开始后观察到过敏反应。这可能是由于抗原性物质的溢出所致。以下治疗期耐受性良好。在此描述的其他病例中未观察到严重的毒副作用。
