[Influence of long term hemodialysis treatment on TSH secretion in patients with chronic renal failure].

UNLABELLED

In patients with advanced chronic renal failure many disturbances in functioning of pituitary-thyroid axis are well documented. The present paper aimed to assess the influence of duration of haemodialysis treatment on the basal and stimulated TSH secretion. 17 nondialyzed uraemic patients, 15 dialysed up to 50 months, 11 dialysed for 51-100 months, 11 dialysed for more than 100 months and 14 control subjects were examined. In all subjects TSH levels were assessed before and 15, 30, 45, 60 and 120 minutes after TRH administration (400 micrograms i.v.).

RESULTS

1. Nondialyzed and dialysed patients up to 50 months showed significantly lower basal values of TSH as compared with the patients dialysed longer and with normal subjects. 2. Areas over basal values of TSH were distinctly lower in all patients as compared with control group. 3. Negative significant correlation between the duration of dialysis therapy and area over basal TSH values was found.

CONCLUSION

Duration of haemodialysis treatment influences markedly secretion of TSH in chronic renal failure.