Hasegawa K, Matsushita Y, Otoma S, Hamada N, Nishizawa Y
Acta Endocrinol (Copenh). 1975 Aug;79(4):635-43. doi: 10.1530/acta.0.0790635.
Serum levels of TSH and GH were measured by radioimmunoassay after iv injection of 500 mug of TRH in 9 undialysed patients and 12 dialysed patients with chronic renal failure and in 6 healthy subjects. The basal level of the serum TSH was significantly higher in patients with chronic renal failure than that in healthy subjects. In healthy subjects, serum TSH rose to a maximum level 30 min after TRH injection, while in patients with chronic renal failure, serum TSH rose to a maximum level 60 min after TRH injection. The mean maximum increment of serum TSH in healthy subjects was significantly higher than that in patients with chronic renal failure. Although TSH levels rapidly decreased after initial rise at 30 min after TRH administration in healthy subjects, these did not show significant changes at 60 and 120 min compared with values at 30 min after TRH administration in both dialysed and undialysed patients. The basal level of serum GH was significantly higher in dialysed patients with chronic renal failure than in healthy subjects. Serum GH level was much higher in dialysed patients at 30 min after TRH INJECTION COMPARED WITH THAT IN HEALTHY SUBJECTS. These findings may indicate that the response of the pituitary to TRH is abnormal and that the turnover of TSH and GH is decreased in patients with chronic renal failure.
对9例未透析的慢性肾衰竭患者、12例透析的慢性肾衰竭患者以及6名健康受试者静脉注射500微克促甲状腺激素释放激素（TRH）后，采用放射免疫分析法测定血清促甲状腺激素（TSH）和生长激素（GH）水平。慢性肾衰竭患者血清TSH的基础水平显著高于健康受试者。在健康受试者中，TRH注射后30分钟血清TSH升至最高水平，而在慢性肾衰竭患者中，TRH注射后60分钟血清TSH升至最高水平。健康受试者血清TSH的平均最大增加值显著高于慢性肾衰竭患者。尽管健康受试者在TRH给药后30分钟初始升高后TSH水平迅速下降，但与透析和未透析患者TRH给药后30分钟的值相比，在60分钟和120分钟时这些值没有显著变化。透析的慢性肾衰竭患者血清GH的基础水平显著高于健康受试者。与健康受试者相比，透析患者在TRH注射后30分钟时血清GH水平要高得多。这些发现可能表明慢性肾衰竭患者垂体对TRH的反应异常，且TSH和GH的更新率降低。
