[Influence of long term hemodialysis treatment on total, free and reverse triiodothyronine serum concentration in patients with chronic renal failure].

UNLABELLED

Many disturbances is functioning of pituitary-thyroid axis in patients with advanced chronic renal failure are well documented. The present paper aimed to assess the influence of duration of haemodialysis treatment on the basal and after TRH stimulation TT3, fT3 and rT3 serum concentration in uremic patients. 17 nondialyzed uraemic patients, 15 dialysed up to 50 months, 11 dialysed for 51-100 months, 11 dialysed for more than 100 months and 14 control subjects were examined. In all subjects TT3, fT3, and rT3 levels were assessed before and after TRH administration (400 micrograms i.v.).

RESULTS

1. All patients showed significantly lower basal TT3 in comparison with normal subjects. 2. Nondialyzed and dialysed patients up to 50 months showed significantly lower basal values of fT3 as compared with the patients dialysed longer and with normal subjects. 3. The basal rT3 in the patients dialysed over 50 months were significantly higher then in nondialyzed, dialyzed up to 50 months and in the control group. 4. Areas over basal values of TT3 and fT3 were distinctly lower in all patients as compared with control group and significantly higher in patients dialysed from 51-100 months than in patients dialysed up to 50 months. 5. Areas over basal rT3 values did not show any significant differences in all examined groups. 6. Positive significant correlations were found between the duration of dialysis therapy and basal TT3, fT3 and rT3.

CONCLUSIONS

Duration of haemodialysis treatment is a important factor influencing serum TT3, fT3 and rT3 concentration. This effect is observed in partial normalisation of: a) basal TT3 and fT3, b) reactivity of TT3 and fT3 after THR administration.