Gullotta F, Masini T, Scarlato G, Kuchelmeister K
Institut für Neuropathologie, Universität Münster, FRG.
Pathol Res Pract. 1992 Dec;188(8):964-72. doi: 10.1016/s0344-0338(11)81239-2.
A case of progressive multifocal leukoencephalopathy (PML) is reported, detected at autopsy of a 30-year-old patient. The clinical picture was characterized by a progressive course of mental deterioration and ingravescent neurological symptoms. The patient was HIV-negative. He died of bronchopneumonia, after a clinical course of 13 months. Autopsy disclosed pulmonary tuberculosis with involvement of regional lymph nodes. In the brain, besides numerous PML-foci of varying age and structure, a pleomorphic astrocytoma was found in the white matter of the right parietal lobe. In the brain stem glial proliferation resembling diffuse gliomatosis was also present. In situ hybridization revealed Papova-virus (JCV) in oligoglial nuclei, but not in neoplastic astrocytes. This is the third report on the concomitant occurrence of PML and glioma in man.
报告了一例进行性多灶性白质脑病（PML），在一名30岁患者的尸检中被发现。临床表现为精神衰退和逐渐加重的神经症状的进行性病程。该患者HIV检测为阴性。在13个月的临床病程后，他死于支气管肺炎。尸检发现有肺结核伴区域淋巴结受累。在大脑中，除了有许多不同年龄和结构的PML病灶外，在右顶叶白质中还发现了多形性星形细胞瘤。在脑干中也存在类似弥漫性胶质瘤病的胶质细胞增生。原位杂交在少突胶质细胞核中发现了乳头多瘤空泡病毒（JCV），但在肿瘤性星形胶质细胞中未发现。这是关于人类中PML和胶质瘤同时发生的第三篇报告。
