Wee W R, Youn D H
Department of Ophthalmology, College of Medicine, Seoul National University, Korea.
Korean J Ophthalmol. 1992 Dec;6(2):62-8. doi: 10.3341/kjo.1992.6.2.62.
Posterior lip sclerectomies were performed in rabbits and cytosine arabinoside (Ara-C) was applied by topical instillation or subconjunctival injection. In both groups, the mean intraocular pressure (IOP) of the treated eyes was significantly lowered at postoperative week 1 and 2, but there was no significant difference between the mean IOP of the control eyes and that of the treated eyes at postoperative week 3 and 4. In both groups, at postoperative week 2, the sclerectomy sites of the control eyes were totally occluded by granulation tissue, but those of the treated eyes were partially replaced by granulation tissue. At postoperative week 4, the sclerectomy sites of the treated eyes were totally occluded by the granulation tissue ultimately in both groups. There were no differences in the mean IOP and the histologic finding of the treated eyes between the topical instillation group and the subconjunctival injection group. We concluded that either topical instillation or subconjunctival injection of Ara-C can delay wound healing at the surgical site after glaucoma filtering surgery in rabbits.
对兔子进行后唇巩膜切除术，并通过局部滴注或结膜下注射应用阿糖胞苷（Ara-C）。在两组中，治疗眼的平均眼压在术后第1周和第2周均显著降低，但在术后第3周和第4周，对照眼与治疗眼的平均眼压之间无显著差异。在两组中，术后第2周，对照眼的巩膜切除部位完全被肉芽组织阻塞，但治疗眼的巩膜切除部位部分被肉芽组织取代。术后第4周，两组中治疗眼的巩膜切除部位最终均完全被肉芽组织阻塞。局部滴注组和结膜下注射组治疗眼的平均眼压和组织学结果无差异。我们得出结论，局部滴注或结膜下注射Ara-C均可延迟兔青光眼滤过术后手术部位的伤口愈合。
