Neville E, Mills R G, Jash D K, Mackinnon D M, Carstairs L S, James D G
Thorax. 1976 Dec;31(6):660-4. doi: 10.1136/thx.31.6.660.
In a series of 34 patients with sarcoidosis affecting the upper respiratory tract and nose, 26 had lupus pernio (LP) and 17 had sarcoidosis of the upper respiratory tract (SURT). In nine patients these features coexisted. A patient presenting with SURT carried a 50% risk of developing LP although one feature could be present without the other. Both were disorders of women of the child-bearing years of life. SURT, like LP, was an indicator of chronic fibrotic sarcoidosis, developing insidiously and progressing indolently over the years. It was complicated by ulceration, septal perforation, and LP. Three patients had nasal septal perforations, in two instances following submucous resection. This operation is contraindicated in patients with active sarcoidosis, particularly when granulomas are found on nasal biopsy. The Kveim-Siltzbach skin test was positive in all patients with SURT, making it invaluable in the differential diagnosis of granuloma of the nasal cavity.
在一组34例累及上呼吸道和鼻子的结节病患者中，26例有冻疮样狼疮（LP），17例有上呼吸道结节病（SURT）。9例患者同时存在这些特征。表现为SURT的患者有50%的风险发展为LP，尽管一种特征可能单独出现。两者都是育龄期女性的疾病。SURT与LP一样，是慢性纤维化结节病的一个指标，发病隐匿，多年来进展缓慢。它会并发溃疡、鼻中隔穿孔和LP。3例患者有鼻中隔穿孔，其中2例发生在黏膜下切除术后。活动性结节病患者禁忌进行此手术，尤其是在鼻活检发现肉芽肿时。所有SURT患者的Kveim-Siltzbach皮肤试验均为阳性，这使其在鼻腔肉芽肿的鉴别诊断中具有极高价值。
