Carboni D, Ehrich M, Dyer K, Jortner B S
Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg 24061.
Neurotoxicology. 1992 Winter;13(4):723-33.
Adult male Long-Evans rats and White Leghorn hens were given 30 mg/kg mipafox ip. Administration of this organophosphorus ester resulted in > or = 89% inhibition of brain and spinal cord neurotoxic esterase activity in both species 4 hr after dosing. Our sequential, comparative study of the bilateral mipafox-induced neuropathy in the medulla and cervical spinal cord in hens and rats demonstrated that the rats had well-developed, vacuolar axonopathic lesions in the fasciculus gracilis by post-dosing day 7. Severely affected rats with such lesions were noted through day 21, but not subsequently (days 28 and 35). The hen had a slower developing, but more severe, consistent and longer lasting neuropathy than the rat. In these birds, lesions in the medulla and rostral cervical spinal cord levels were more extensive, involving large regions of both the spinocerebellar tracts and fasciculus gracilis. Neuropathic changes, including myelinated fiber axonopathy and Wallerian-like degeneration, were prominent from days 14 - 35 in hens, and were associated with prominent gliosis in the later stages.
成年雄性长 Evans 大鼠和白来航鸡腹腔注射 30 mg/kg 的丙胺氟磷。给药 4 小时后，该有机磷酸酯的施用导致两种动物的脑和脊髓神经毒性酯酶活性抑制率≥89%。我们对母鸡和大鼠双侧丙胺氟磷诱导的延髓和颈脊髓神经病变进行的序贯比较研究表明，给药后第 7 天，大鼠的薄束出现了发育良好的空泡性轴索性病变。出现此类病变的严重受影响大鼠在第 21 天被观察到，但之后（第 28 天和第 35 天）未再出现。母鸡的神经病变发展较慢，但比大鼠更严重、更持续且持续时间更长。在这些鸟类中，延髓和颈脊髓头端水平的病变更广泛，累及脊髓小脑束和薄束的大片区域。从第 14 天到第 35 天，母鸡出现了明显的神经病变变化，包括有髓纤维轴索性病变和类华勒氏变性，后期还伴有明显的胶质细胞增生。
