Mikami Y, Takahashi A, Yazawa K, Terao K, Ueno Y
Department of Experimental Chemotherapy, Chiba University, Japan.
Mycoses. 1992 Nov-Dec;35(11-12):321-7. doi: 10.1111/j.1439-0507.1992.tb00888.x.
The in vitro combination effect of two azole antimycotics, miconazole and fluconazole, against Candida albicans was studied. When minimum (MIC) and sub-minimum (sub-MIC) inhibitory concentration and fractional inhibitory concentration (FIC) determinations were made, a synergistic interaction of the two agents at the concentration well below their individual MICs (at sub-MIC levels) was evidenced. The FIC index values ranged from 0.3 to 1.0 and the synergy was characterized by the potentiation of fluconazole activity with miconazole. The synergistic effect was also confirmed by a turbidometric method. On the other hand, such a synergistic effect against Candida krusei was not confirmed.
研究了两种唑类抗真菌药咪康唑和氟康唑对白色念珠菌的体外联合作用。当测定最低抑菌浓度（MIC）、亚最低抑菌浓度（sub-MIC）和部分抑菌浓度（FIC）时，发现这两种药物在远低于其各自MIC的浓度（亚MIC水平）下存在协同相互作用。FIC指数值范围为0.3至1.0，协同作用表现为咪康唑增强了氟康唑的活性。通过比浊法也证实了协同作用。另一方面，未证实对克柔念珠菌有这种协同作用。
