硝酸异康唑与克霉唑治疗由串珠状亨德逊霉、透明赛多孢和皮肤癣菌引起的足部及指甲感染的对比

Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes.

作者信息

Oyeka C A, Gugnani H C

机构信息

Department of Microbiology, University of Nigeria, Nsukka.

出版信息

Mycoses. 1992 Nov-Dec;35(11-12):357-61. doi: 10.1111/j.1439-0507.1992.tb00894.x.

DOI:10.1111/j.1439-0507.1992.tb00894.x

PMID:1302811

Abstract

A total of 40 coal miners, 35 with culturally proven mycotic infections of the feet and 5 with similarly proven infections of toenails due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes, were treated with 1% cream of either isoconazole nitrate (Travogen) or clotrimazole (Canestan) for 4 weeks. The clinical cure rates for the isoconazole-treated group for itching, inflammation, scaling and maceration in the cases of foot infections were 89, 88, 83 and 83% respectively. For the clotrimazole-treated group, the cure rates were 76, 71, 82 and 80% respectively, for the similar symptoms. Toe web was the commonest site of infection and also most easily treated with either clotrimazole or isoconazole. The clinical and mycological cure rates 6 weeks after treatment were 80% for the isoconazole-treated group and 70% for the clotrimazole-treated group but the difference was not statistically significant (P > 0.01). None of the cases of toenail infection could be cured by treatment with either of the two drugs.

摘要

共有40名煤矿工人，其中35人经培养证实足部有真菌感染，5人经同样方法证实因串珠镰刀菌、透明赛多孢菌和皮肤癣菌导致趾甲感染，使用1%硝酸异康唑乳膏（曲沃真）或克霉唑乳膏（凯妮汀）治疗4周。在足部感染病例中，异康唑治疗组对于瘙痒、炎症、脱屑和浸渍的临床治愈率分别为89%、88%、83%和83%。对于类似症状，克霉唑治疗组的治愈率分别为76%、71%、82%和80%。趾间是最常见的感染部位，使用克霉唑或异康唑治疗也最容易治愈。治疗6周后的临床和真菌学治愈率，异康唑治疗组为80%，克霉唑治疗组为70%，但差异无统计学意义（P>0.01）。两种药物治疗均无法治愈任何一例趾甲感染病例。