Sadykova R E, Kodentsova V M, Sokol'nikov A A, Vrzhesinskaia O A, Beketova N A, Dreval' A V, Spirichev V Iu
Probl Endokrinol (Mosk). 1993 May-Jun;39(3):40-2.
Measurements of blood and liver water-soluble vitamins and of their metabolites urinary excretion helped characterize these vitamins metabolism in rats with streptozotocin-induced diabetes. The liver levels of recovered ascorbic acid and total thiamin were virtually the same in diabetic and intact rats. Essential changes of riboflavin metabolism were revealed in diabetes: riboflavin urinary excretion was five times higher than that in intact animals, the blood serum levels being the same in health and disease, whereas liver riboflavin levels in diabetic rats had a trend to lowering. The activities of FAD-dependent hepatic enzymes were the same in both groups. 4-pyridoxylic acid excretion was increased and 1-methylnicotinamide excretion reduced in diabetic rats.
对血液和肝脏中水溶性维生素及其代谢产物尿排泄的测量有助于表征链脲佐菌素诱导的糖尿病大鼠体内这些维生素的代谢情况。糖尿病大鼠和正常大鼠肝脏中回收的抗坏血酸和总硫胺素水平实际上相同。糖尿病时核黄素代谢出现显著变化：核黄素尿排泄量比正常动物高五倍，健康和患病时血清水平相同，而糖尿病大鼠肝脏中的核黄素水平有降低趋势。两组中依赖黄素腺嘌呤二核苷酸的肝脏酶活性相同。糖尿病大鼠中4-吡哆酸排泄增加而1-甲基烟酰胺排泄减少。
