Sandyk R
NeuroCommunication Research Laboratories, Danbury, CT 06811.
Int J Neurosci. 1992 Sep;66(1-2):97-106. doi: 10.3109/00207459208999794.
Application of external weak magnetic fields recently has been reported to be efficacious in the treatment of a 62-year-old patient with idiopathic Parkinson's disease (PD) complicated by levodopa-induced fluctuations in motor response ("on-off"). I report an additional case of a 67-year-old man with idiopathic PD and levodopa-related motor fluctuations who likewise experienced marked and sustained improvement in Parkinsonian symptoms and amelioration of "on-off" symptoms following the application of external weak magnetic fields. Based on these observations it is concluded that artificial weak magnetic fields may be beneficial for the treatment of PD complicated by levodopa-related "on-off" phenomenon. Furthermore, since in experimental animals external magnetic fields alter the secretion of melatonin, which in turn has been shown to regulate striatal and mesolimbic dopamine-mediated behaviors, it is proposed that the antiParkinsonian effects of weak magnetic fields are mediated via the pineal gland.
最近有报道称，外部弱磁场应用于一名62岁特发性帕金森病（PD）患者的治疗有效，该患者伴有左旋多巴引起的运动反应波动（“开-关”现象）。我报告了另外一例67岁男性特发性PD患者，其有左旋多巴相关的运动波动，在应用外部弱磁场后，帕金森症状同样显著且持续改善，“开-关”症状也有所缓解。基于这些观察结果得出结论，人工弱磁场可能有助于治疗伴有左旋多巴相关“开-关”现象的PD。此外，由于在实验动物中，外部磁场会改变褪黑素的分泌，而褪黑素已被证明可调节纹状体和中脑边缘多巴胺介导的行为，因此有人提出弱磁场的抗帕金森作用是通过松果体介导的。
