Sandyk R, Iacono R P
NeuroCommunication Research Laboratories, Danbury, CT 06811.
Int J Neurosci. 1994 Sep;78(1-2):111-22. doi: 10.3109/00207459408986050.
Extracranial treatment with magnetic fields (MF) in the picoTesla range has been shown an efficacious treatment modality in the management of Parkinsonism. The mechanisms by which such extremely weak MF improve Parkinsonian symptoms are unknown. As the pineal gland has been shown to function as a "magnetosensor" and since exposure to various intensities of MF disrupts melatonin secretion, it has been proposed that the beneficial effects of MF in Parkinsonism are partly mediated through the actions of pineal melatonin. Animal studies indicate that externally applied MF also influence the activity of the opioid peptides which have been implicated in a broad range of pathological conditions including Parkinsonism. To explore whether the beneficial effects of MF in Parkinsonism involve the mediation of the opioid systems and following informed consent, we administered the opiate receptor antagonist naltrexone (50 mg, P.O.) to a Parkinsonian patient after he showed improvement of symptoms with application of MF. Results of the trial showed that naltrexone partially reversed the antiparkinsonian effects of MF thus suggesting that opioid peptides are involved in mediating the clinical effects of these extremely weak MF in Parkinsonism. These results also suggest that intact opioid systems may be required for a full expression of the antiparkinsonian effect of picoTesla range MF.
在皮特斯拉范围内用磁场（MF）进行颅外治疗已被证明是治疗帕金森病的一种有效方法。这种极弱的MF改善帕金森病症状的机制尚不清楚。由于松果体已被证明起到“磁传感器”的作用，并且由于暴露于不同强度的MF会干扰褪黑素分泌，因此有人提出MF在帕金森病中的有益作用部分是通过松果体褪黑素的作用介导的。动物研究表明，外部施加的MF也会影响阿片肽的活性，而阿片肽与包括帕金森病在内的广泛病理状况有关。为了探讨MF在帕金森病中的有益作用是否涉及阿片系统的介导，在获得知情同意后，我们在一名帕金森病患者在应用MF后症状改善时，给他服用了阿片受体拮抗剂纳曲酮（50毫克，口服）。试验结果表明，纳曲酮部分逆转了MF的抗帕金森病作用，因此表明阿片肽参与介导这些极弱的MF在帕金森病中的临床作用。这些结果还表明，完整的阿片系统可能是皮特斯拉范围MF抗帕金森病作用充分发挥所必需的。
