Sandyk R
NeuroCommunication Research Laboratories, Danbury, CT 06811.
Int J Neurosci. 1994 Jan-Feb;74(1-4):191-201. doi: 10.3109/00207459408987239.
Recently, I reported that extracranial treatment with picoTesla range magnetic fields (MF) is an effective, safe, and revolutionary modality in the management of Parkinsonism including those patients manifesting levodopa-induced motor complications. This treatment, which has emerged as a potentially more advantageous modality than pharmacologic therapy, also produces improvements in nonmotor aspects of the disease including mood, cognitive functions, sleep, pain, appetite, autonomic functions, and sexual behavior, which are usually minimally, if at all, ameliorated by long term therapy with levodopa or anticholinergic agents. The present communication concerns a 69 year old Parkinsonian patient who, following a series of two treatments with extracranial picoTesla range MF on two separate days, improved to the point where he was able to discontinue most of his antiparkinsonian medications for a period of two weeks without experiencing deterioration in symptoms. On the third week he began to develop recurrence of symptoms and resumed taking his regular medications. At the end of the fourth week the patient received a series of four magnetic treatments on four successive days after he completely discontinued his antiparkinsonian medications. During this period he experienced a remarkable improvement in motor disability as well as in cognitive functions (i.e., visuospatial performance), mood, sleep, appetite, bowel functions and resolution of pain in the lower extremity. This report attests to the antiparkinsonian efficacy of picoTesla range MF and suggests that this treatment, when applied on a regular basis, may reduce the requirement for antiparkinsonian medications. This observation, when confirmed in a larger cohort of patients, may carry important implications for the therapy of Parkinsonism as it may offer an alternative treatment for patients who develop levodopa failure or experience intolerable side effects from dopaminergic medication. The observation that magnetic treatment improved the patient's symptoms while being off dopaminergic therapy supports the role of nondopaminergic mechanisms in the pathophysiology of Parkinsonism.
最近，我报告称，用皮特斯拉级别的磁场（MF）进行颅外治疗是帕金森病管理中一种有效、安全且具有革命性的治疗方式，包括那些出现左旋多巴诱导的运动并发症的患者。这种治疗方式已成为一种比药物治疗更具潜在优势的方法，它还能改善该疾病的非运动方面，包括情绪、认知功能、睡眠、疼痛、食欲、自主神经功能和性行为，而这些方面通常即使有改善，在长期使用左旋多巴或抗胆碱能药物治疗时也极为有限。本报告涉及一名69岁的帕金森病患者，在两天内分两次接受颅外皮特斯拉级MF治疗后，病情改善到能够在两周内停用大部分抗帕金森药物且症状未恶化的程度。在第三周，他开始出现症状复发并重新开始服用常规药物。在第四周结束时，患者在完全停用抗帕金森药物后连续四天接受了一系列四次磁疗。在此期间，他在运动功能障碍以及认知功能（即视觉空间表现）、情绪、睡眠、食欲、肠道功能和下肢疼痛缓解方面都有显著改善。本报告证明了皮特斯拉级MF的抗帕金森病疗效，并表明这种治疗方式如果定期应用，可能会减少抗帕金森药物的使用需求。这一观察结果若能在更大规模的患者队列中得到证实，可能会对帕金森病的治疗产生重要影响，因为它可能为出现左旋多巴失效或对多巴胺能药物产生无法耐受副作用的患者提供一种替代治疗方法。磁疗在患者停用多巴胺能治疗时改善了症状，这一观察结果支持了非多巴胺能机制在帕金森病病理生理学中的作用。
