Zhang Z X, Wang F F
Shanxi Medical College, Taiyuan.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Dec;12(12):741-3, 710.
The crude extract of earthworm which has a thrombolytic effect could significantly decrease the plasma fibrinogen content and euglobulin lysis time (P < 0.01). An enzymatic preparation, containing many fibrinolytic enzymes, was prepared from the crude extract by ammonium sulphate precipitation and DEAE-cellulose chromatography. When administered in rabbits, the enzymatic preparation had an effect in hemorheology improvement. The experiment shows the enzymatic preparation could obviously lower the aggregation of platelets, decrease the viscosity of whole blood and plasma as well as the index of erythrocyte rigidity significantly (P < 0.001). All these effects demonstrated its ability in promoting blood circulation to remove stasis.
具有溶栓作用的蚯蚓粗提物可显著降低血浆纤维蛋白原含量及优球蛋白溶解时间（P<0.01）。通过硫酸铵沉淀和DEAE-纤维素柱层析从粗提物中制备了一种含有多种纤溶酶的酶制剂。给家兔用药后，该酶制剂具有改善血液流变学的作用。实验表明，该酶制剂能明显降低血小板聚集率，显著降低全血和血浆黏度以及红细胞刚性指数（P<0.001）。所有这些作用都证明了其活血化瘀的能力。
