JEMSKI J V, FLICK J A, STINEBRING W R
J Exp Med. 1953 Mar;97(3):439-53. doi: 10.1084/jem.97.3.439.
The results obtained in this study indicate that serum protease is not activated by either a rabbit or guinea pig antiovalbumin-ovalbumin system, in vitro. A precipitin reaction occurring in the presence of a serum protease precursor of three species (human, rabbit, and guinea pig) failed to activate the protease precursor. Furthermore, particulate material as preformed precipitates could not be shown to activate the protease of either human or rabbit serum or their euglobulin fractions. The material presented seems to be further evidence against the postulated role of serum protease in immunologic systems.
本研究获得的结果表明,在体外,兔或豚鼠抗卵清蛋白-卵清蛋白系统均不能激活血清蛋白酶。在三种物种(人类、兔和豚鼠)的血清蛋白酶前体存在的情况下发生的沉淀反应未能激活该蛋白酶前体。此外,预先形成沉淀的颗粒物质不能激活人或兔血清及其优球蛋白组分的蛋白酶。所呈现的材料似乎进一步证明了血清蛋白酶在免疫系统中假定作用的不成立。