Torrado J, Correa P, Ruiz B, Zavala D, Bara J
Department of Anatomic Pathology, Hospital Nuestra Sra. de Aranzazu, San Sebastian, Spain.
Cancer Epidemiol Biomarkers Prev. 1992 Mar-Apr;1(3):199-205.
A prospective study with two gastric biopsies taken several years apart was carried out in 117 subjects with intestinal metaplasia who are of the Lewis(a-b+) phenotype. They are residents of a rural Andean region in Colombia displaying very high rates of gastric cancer. The anomalous expression of Lewis(a) antigens in the metaplastic epithelium carried a significantly increased risk of colonic metaplasia and dysplasia. Such risk was much higher when the simultaneous expression of sulfomucins and Lewis(a) antigen was observed.
对117名具有肠化生且为Lewis(a-b+)表型的受试者进行了一项前瞻性研究，两次胃活检相隔数年。他们是哥伦比亚安第斯山区农村的居民，胃癌发病率非常高。化生上皮中Lewis(a)抗原的异常表达使结肠化生和发育异常的风险显著增加。当观察到硫黏液素和Lewis(a)抗原同时表达时，这种风险要高得多。
