Torrado J, Ruiz B, Garay J, Cosme A, Arenas J I, Bravo J C, Fontham E, Correa P
Hospital Aránzazu, San Sebastián, Spain.
Cancer Epidemiol Biomarkers Prev. 1997 Apr;6(4):287-9.
The closely interrelated Lewis, secretor, and ABO phenotypes have long been linked to the risk of peptic ulcers and gastric cancer and may modulate the interaction between Helicobacter pylori and the gastric surface epithelium. We explored the association between the expression of sulfomucins in gastric intestinal metaplasia, a known marker of preneoplastic progression, and the expression of Lewis, secretor, and ABO phenotypes, in 523 subjects from Nariño, Colombia, and 856 subjects from northern Spain. In both study populations, Lewis (a+/b-) and nonsecretor phenotypes showed a significant positive association with the expression of sulfomucins (odds ratios, 2.4 and 2.6, respectively).
密切相关的Lewis、分泌型和ABO血型表型长期以来一直与消化性溃疡和胃癌风险相关联，并且可能调节幽门螺杆菌与胃表面上皮之间的相互作用。我们在来自哥伦比亚纳里尼奥的523名受试者和西班牙北部的856名受试者中，探究了胃肠化生（一种已知的肿瘤前进展标志物）中硫黏液素表达与Lewis、分泌型和ABO血型表型表达之间的关联。在两个研究人群中，Lewis（a+/b-）和非分泌型表型均与硫黏液素的表达呈显著正相关（优势比分别为2.4和2.6）。
