Torrado J, Correa P, Ruiz B, Bernardi P, Zavala D, Bara J
Department of Anatomic Pathology, Hospital Nuestra Sra. Aranzazu, San Sebastián, Spain.
Gastroenterology. 1992 Feb;102(2):424-30. doi: 10.1016/0016-5085(92)90086-e.
To explore the dynamics of the progressive loss of cell differentiation observed in the gastric precancerous process, the abnormal expression of Lea antigen in the gastric epithelium was investigated. Gastric biopsy specimens of 122 subjects with Le(a-b+) phenotype who had intestinal metaplasia of the gastric mucosa were studied. The subjects are residents of a rural area in the Colombian Andes with very high risk of gastric cancer. The abnormality was detected with increasing frequency in lesions with other markers of progression of the precancerous process, namely, colonic-type of morphology of the metaplastic cells, expression of sulfomucins, and dysplastic changes. The concomitant expression of the abnormal Lea antigen and sulfomucins was found to be a more reliable marker of more advanced lesions such as colonic metaplasia and dysplasia than either marker alone.
为了探究在胃癌前病变过程中观察到的细胞分化逐渐丧失的动态变化，研究了胃上皮中Lea抗原的异常表达。对122例具有Le(a-b+)表型且胃黏膜有肠化生的受试者的胃活检标本进行了研究。这些受试者是哥伦比亚安第斯山脉一个农村地区的居民，患胃癌的风险非常高。在伴有癌前病变进展的其他标志物（即化生细胞的结肠型形态、硫黏液表达和发育异常改变）的病变中，该异常的检出频率不断增加。发现异常Lea抗原和硫黏液的同时表达比单独任何一种标志物更能可靠地指示诸如结肠化生和发育异常等更晚期病变。
