Majerus P M, Courtois P A
Université Libre de Bruxelles - Laboratoire Facultaire de Stomatologie, Belgium.
J Biol Buccale. 1992 Dec;20(4):241-5.
The susceptibility of Candida albicans (ATCC 10231 and wild strains) to hypo(pseudo)halous ions (OSCN-, OBr-, OI-) produced by the lactoperoxidase system was tested. Six strains of Candida albicans were isolated from swabs taken from the mouths of children with orthodontic appliances and selected on Sabouraud-Chloramphenicol-Actidione agar plates. The survival rate of Candida blastospores after a 30 min exposure to lactoperoxidase system ranged from 79 to 105% in the presence of 615 microM thiocyanate, from 56 to 88% in the presence of 345 microM bromide and from 0 to 4% in the presence of 250 microM iodide. Results showed that only OI- could exert a strong inhibiting effect in vitro on Candida albicans at physiological concentrations. Nevertheless, the activity of the hypoiodite generating system in saliva was found to be under the control of thiocyanate concentration.
测试了白色念珠菌（美国典型培养物保藏中心10231株及野生菌株）对乳过氧化物酶系统产生的次（拟）卤离子（OSCN-、OBr-、OI-）的敏感性。从佩戴正畸矫治器儿童口腔拭子中分离出6株白色念珠菌，并在沙氏-氯霉素-放线菌酮琼脂平板上进行筛选。在615微摩尔硫氰酸盐存在下，白色念珠菌芽生孢子暴露于乳过氧化物酶系统30分钟后的存活率为79%至105%；在345微摩尔溴化物存在下，存活率为56%至88%；在250微摩尔碘化物存在下，存活率为0至4%。结果表明，只有OI-在生理浓度下能在体外对白色念珠菌发挥强烈抑制作用。然而，发现唾液中次碘酸盐生成系统的活性受硫氰酸盐浓度的控制。
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