Shigematsu H, Kobayashi Y
Virchows Arch A Pathol Anat Histol. 1976 Mar 5;369(4):269-82. doi: 10.1007/BF00432449.
Electron microscopic analysis was performed on the development of irreversible glomerular distortion in experimental serum sickness nephritis in the rabbit. In the animals showing transient albuminuria, glomerular hypercellularity was due to the accumulation of monocytes and polymorphonuclear leukocytes and was seen to recover to nearly normal glomerulus. In this condition the glomerular structure was observed to be well preserved throughout the inflammation. In contrast, in the animals showing persistent proteinnuria, a disorganizing process was found in their glomeruli. Mesangial disintegration resulted in collapsed scarring or circumferential mesangial interposition of the glomeruli. Extracapillary exudation, sometimes with the rupture of the glomerular basement membrane, was often associated with granulomatous glomerular lesions or cresent formation. The results showed that the structural disintegration is a fundamental event in the development of progressive glomerulonephritis.
对兔实验性血清病肾炎中不可逆肾小球变形的发展进行了电子显微镜分析。在出现短暂蛋白尿的动物中，肾小球细胞增多是由于单核细胞和多形核白细胞的积聚，并且可见其恢复到几乎正常的肾小球。在这种情况下，整个炎症过程中肾小球结构均观察到保存良好。相比之下，在出现持续性蛋白尿的动物中，其肾小球中发现了一个结构破坏过程。系膜崩解导致肾小球塌陷性瘢痕形成或肾小球系膜环周插入。毛细血管外渗出，有时伴有肾小球基底膜破裂，常与肉芽肿性肾小球病变或新月体形成相关。结果表明，结构破坏是进行性肾小球肾炎发展过程中的一个基本事件。
