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Dynamic control of inositol 1,4,5-trisphosphate-induced Ca2+ release: a theoretical explanation for the quantal release of Ca2+.

作者信息

Swillens S

机构信息

Institut de Recherche Interdisciplinaire, Université Libre de Bruxelles, Belgium.

出版信息

Mol Pharmacol. 1992 Jan;41(1):110-4.

PMID:1310136
Abstract

A theoretical model has been elaborated in order to describe the kinetics of Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3). The model is based on the existence of a key molecule that controls the interconversion of open and closed forms of the Ca2+ channel. The model can quantitatively explain the previously obtained experimental observations that showed that a continuous IP3 stimulus leads to a biphasic Ca2+ release and that successive IP3 additions provoke repetitive bursts of Ca2+ release. Other published interpretations of these observations are discussed.

摘要

相似文献

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Dynamic control of inositol 1,4,5-trisphosphate-induced Ca2+ release: a theoretical explanation for the quantal release of Ca2+.
Mol Pharmacol. 1992 Jan;41(1):110-4.
2
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引用本文的文献

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J Gen Physiol. 2012 Dec;140(6):697-716. doi: 10.1085/jgp.201210804. Epub 2012 Nov 12.
2
A minimal gating model for the cardiac calcium release channel.一种用于心脏钙释放通道的最小门控模型。
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3
Quantal release, incremental detection, and long-period Ca2+ oscillations in a model based on regulatory Ca2+-binding sites along the permeation pathway.
基于沿渗透途径的调节性钙结合位点的模型中的量子释放、增量检测和长周期钙离子振荡。
Biophys J. 1996 Oct;71(4):1714-22. doi: 10.1016/S0006-3495(96)79373-6.
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Transient inositol 1,4,5-trisphosphate-induced Ca2+ release: a model based on regulatory Ca(2+)-binding sites along the permeation pathway.瞬时肌醇1,4,5-三磷酸诱导的Ca2+释放：一种基于沿渗透途径的调节性Ca(2+)结合位点的模型。
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10074-8. doi: 10.1073/pnas.91.21.10074.
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Quantal calcium release and calcium entry in the pancreatic acinar cell.胰腺腺泡细胞中的量子钙释放和钙内流。
Yale J Biol Med. 1992 Sep-Oct;65(5):399-405; discussion 437-40.