Tseng C J, Lin C Y, Wang R L, Chen L J, Chang Y L, Hsieh T T, Pao C C
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Medical College, KweiShan, TaoYuan, Taiwan, Republic of China.
Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):35-40. doi: 10.1016/0002-9378(92)91825-u.
The objective of this study was to examine the possibility of intrauterine human papillomavirus infection of fetuses by transplacental transmission of human papillomavirus before delivery.
Specimens of cervicovaginal cells and peripheral blood mononuclear cells were obtained from 52 consecutive pregnant women in the third trimester of pregnancy. Cord blood specimens were also obtained from the neonates born to these mothers. Presence of human papillomavirus types 16 and 18 deoxyribonucleic acid was analyzed by an in vitro enzymatic deoxyribonucleic acid amplification method.
Human papillomavirus type 16 deoxyribonucleic acid was found in 6 (11.5%) cervicovaginal and in 9 (17.3%) peripheral blood mononuclear cell specimens. Seven cord blood specimens from neonates born to mothers who were positive for peripheral blood mononuclear cell human papillomavirus type 16 deoxyribonucleic acid were found to contain human papillomavirus type 16 deoxyribonucleic acid. One cervicovaginal and two peripheral blood mononuclear cell specimens contained human papillomavirus type 18 deoxyribonucleic acid, but none of the cord blood specimens contained human papillomavirus type 18 deoxyribonucleic acid.
These results seem to suggest possible transplacental transmission of the virus and the potential association of such transmission with the status of human papillomavirus in peripheral blood mononuclear cells.
本研究的目的是检测分娩前胎儿通过胎盘传播感染人乳头瘤病毒的可能性。
从52名连续妊娠晚期孕妇中获取宫颈阴道细胞和外周血单核细胞样本。还从这些母亲所生的新生儿中获取脐带血样本。采用体外酶促脱氧核糖核酸扩增法分析16型和18型人乳头瘤病毒脱氧核糖核酸的存在情况。
在6份（11.5%）宫颈阴道样本和9份（17.3%）外周血单核细胞样本中发现了16型人乳头瘤病毒脱氧核糖核酸。在母亲外周血单核细胞16型人乳头瘤病毒脱氧核糖核酸呈阳性的新生儿的7份脐带血样本中，发现含有16型人乳头瘤病毒脱氧核糖核酸。1份宫颈阴道样本和2份外周血单核细胞样本含有18型人乳头瘤病毒脱氧核糖核酸，但所有脐带血样本均未含有18型人乳头瘤病毒脱氧核糖核酸。
这些结果似乎表明该病毒可能通过胎盘传播，且这种传播可能与外周血单核细胞中人乳头瘤病毒的状态有关。
