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The possibilities of change in amino acids of a protein are discussed in terms of a point mutation. 2. Whereas Met and Trp are forced to change due to a point mutation, other amino acids (Ala, Arg, Gly, Leu, Pro and Val) have a probability of 1/3 to survive in the sequence. 3. On basis of these considerations, the genome from 5 strains (CSP, C3Ind, O1K, A10 and A12) of the foot-and-mouth disease virus was studied. 4. A hypothetical genealogic tree for these strains is suggested, where CSP and C3Ind are close and also A10 and A12. O1K is closer to A10 and A12 than to CSP or C3Ind.

从点突变的角度讨论了蛋白质氨基酸发生变化的可能性。2. 由于点突变，甲硫氨酸（Met）和色氨酸（Trp）会被迫发生变化，而其他氨基酸（丙氨酸（Ala）、精氨酸（Arg）、甘氨酸（Gly）、亮氨酸（Leu）、脯氨酸（Pro）和缬氨酸（Val））在序列中存活的概率为三分之一。3. 基于这些考虑，对口蹄疫病毒5个毒株（CSP、C3Ind、O1K、A10和A12）的基因组进行了研究。4. 提出了这些毒株的一个假设系谱树，其中CSP和C3Ind关系密切，A10和A12也关系密切。O1K与A10和A12的关系比与CSP或C3Ind的关系更密切。

The possibilities of change in amino acids of a protein are discussed in terms of a point mutation. 2. Whereas Met and Trp are forced to change due to a point mutation, other amino acids (Ala, Arg, Gly, Leu, Pro and Val) have a probability of 1/3 to survive in the sequence. 3. On basis of these considerations, the genome from 5 strains (CSP, C3Ind, O1K, A10 and A12) of the foot-and-mouth disease virus was studied. 4. A hypothetical genealogic tree for these strains is suggested, where CSP and C3Ind are close and also A10 and A12. O1K is closer to A10 and A12 than to CSP or C3Ind.

从点突变的角度讨论了蛋白质氨基酸发生变化的可能性。2. 由于点突变，甲硫氨酸（Met）和色氨酸（Trp）会被迫发生变化，而其他氨基酸（丙氨酸（Ala）、精氨酸（Arg）、甘氨酸（Gly）、亮氨酸（Leu）、脯氨酸（Pro）和缬氨酸（Val））在序列中存活的概率为三分之一。3. 基于这些考虑，对口蹄疫病毒5个毒株（CSP、C3Ind、O1K、A10和A12）的基因组进行了研究。4. 提出了这些毒株的一个假设系谱树，其中CSP和C3Ind关系密切，A10和A12也关系密切。O1K与A10和A12的关系比与CSP或C3Ind的关系更密切。

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