赖甲环素在反应性关节炎长期治疗中的抗胶原酶解潜力。
The anticollagenolytic potential of lymecycline in the long-term treatment of reactive arthritis.
作者信息
Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub L M, Konttinen Y T
机构信息
Department of Medical Chemistry, University of Helsinki, Finland.
出版信息
Arthritis Rheum. 1992 Feb;35(2):195-8. doi: 10.1002/art.1780350211.
OBJECTIVE
We sought to determine the antiinflammatory properties of lymecycline in the long-term treatment of reactive arthritis (ReA).
METHODS
Quantitative assay of collagenase activity by densitometry after sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
RESULTS
Therapeutic levels of lymecycline do not directly inhibit the activity of human neutrophil interstitial collagenase, but can prevent the oxidative activation of latent human neutrophil collagenase.
CONCLUSION
This non-antimicrobial, anticollagenolytic property of lymecycline may contribute to its therapeutic efficacy in the treatment of patients with ReA.
目的
我们试图确定赖甲环素在反应性关节炎（ReA）长期治疗中的抗炎特性。
方法
在十二烷基硫酸钠-聚丙烯酰胺凝胶电泳后通过光密度法对胶原酶活性进行定量测定。
结果
赖甲环素的治疗水平并不直接抑制人中性粒细胞间质胶原酶的活性，但可防止潜在的人中性粒细胞胶原酶的氧化激活。
结论
赖甲环素的这种非抗菌、抗胶原酶解特性可能有助于其在治疗ReA患者中的疗效。
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