Lauhio A, Konttinen Y T, Tschesche H, Nordström D, Salo T, Lähdevirta J, Golub L M, Sorsa T
Department of Internal Medicine, Aurora Hospital, Helsinki, Finland.
Antimicrob Agents Chemother. 1994 Feb;38(2):400-2. doi: 10.1128/AAC.38.2.400.
The aim of this work was to determine whether human polymorphonuclear neutrophilic interstitial collagenase (matrix metalloproteinase 8 [MMP-8]) levels are reduced during long-term doxycycline treatment in humans with reactive arthritis. Serum MMP-8 levels were reduced (mean +/- standard error of the mean, 678.9 +/- 185.6 versus 491.2 +/- 144.8 ng of MMP-8 per ml), but not statistically significantly. However, the reduction of salivary MMP-8 levels was statistically significant (3,729 +/- 1,905.3 versus 1,866 +/- 780.0 ng of MMP-8 per ml, P < 0.05). This study demonstrated that a 2-month regimen of doxycycline can reduce MMP-8 levels in serum and especially in body fluids (i.e., saliva) containing inflammatory exudates and thus may contribute to reduced tissue destruction.
这项研究的目的是确定在长期使用强力霉素治疗反应性关节炎患者的过程中，人类多形核嗜中性粒细胞间质胶原酶（基质金属蛋白酶8 [MMP-8]）水平是否会降低。血清MMP-8水平有所降低（平均值±平均标准误差，每毫升MMP-8为678.9±185.6 ng，而治疗后为491.2±144.8 ng），但差异无统计学意义。然而，唾液中MMP-8水平的降低具有统计学意义（每毫升MMP-8为3,729±1,905.3 ng，而治疗后为1,866±780.0 ng，P < 0.05）。这项研究表明，为期2个月的强力霉素治疗方案可降低血清中尤其是含有炎性渗出物的体液（即唾液）中的MMP-8水平，因此可能有助于减少组织破坏。
