猴病毒40（SV40）小t抗原在体外抑制SV40 DNA复制。
Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro.
作者信息
Carbone M, Hauser J, Carty M P, Rundell K, Dixon K, Levine A S
机构信息
Section on Viruses and Cellular Biology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
出版信息
J Virol. 1992 Mar;66(3):1804-8. doi: 10.1128/JVI.66.3.1804-1808.1992.
Abstract
We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.
摘要
我们描述了猿猴病毒40小t抗原的一种生化功能，即在体外复制系统中抑制猿猴病毒40大T抗原介导的病毒DNA复制。我们的结果表明，在该系统中，小t抗原可阻止蛋白磷酸酶2A介导的大T抗原激活。
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