Thamavit W, Moore M A, Ruchirawat S, Ito N
Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Cancer Lett. 1992 Jan 31;61(3):229-32. doi: 10.1016/0304-3835(92)90292-4.
The effects of repeated praziquantel administration subsequent to dimethylnitrosamine (DMN) treatment of Syrian hamsters were investigated. The antihelminthic drug was given (200 mg/kg body wt. as a suspension in corn oil, by i.g. intubation) 11 times at 2 week intervals starting at week 4 after initial 20 mg/kg DMN i.p. injections at weeks 0 and 2. Sacrifice at week 28 revealed no differences in either hepatocellular or cholangiocellular lesion development between carcinogen-initiated groups with or without antihelminthic treatment. No lesions were observed in the praziquantel alone or untreated groups. The results thus indicate no promotion potential for praziquantel on nitrosamine-induced lesions in the hamster liver.
研究了对叙利亚仓鼠进行二甲基亚硝胺（DMN）处理后重复给予吡喹酮的效果。在第0周和第2周经腹腔注射20mg/kg DMN后，从第4周开始，以2周的间隔经口插管给予抗蠕虫药（200mg/kg体重，以玉米油悬浮液形式），共给药11次。在第28周处死动物时发现，接受致癌物启动且接受或未接受抗蠕虫治疗的组之间，肝细胞或胆管细胞病变的发展没有差异。在单独使用吡喹酮组或未治疗组中未观察到病变。因此，结果表明吡喹酮对仓鼠肝脏中亚硝胺诱导的病变没有促进作用。
