唐氏综合征中额外的21号染色体的起源。
Origin of the extra chromosome no. 21 in Down's syndrome.
作者信息
Wagenbichler P, Killian W, Rett A, Schnedl W
出版信息
Hum Genet. 1976 Apr 15;32(1):13-6. doi: 10.1007/BF00569971.
PMID:131104
Abstract
Eighteen of 38 examined families with children with Down's syndrome showed polymorphisms of chromosome 21 elucidating the origin of the extra chromosome 21. Maternal origin was found in 10 cases and paternal origin in 8 cases. In both sexes errors occurred both in the first and in the second meiotic division.
摘要
在38个有唐氏综合征患儿的被检测家庭中，有18个家庭显示出21号染色体多态性，从而阐明了额外21号染色体的起源。发现10例起源于母亲，8例起源于父亲。在男女两性中，第一次减数分裂和第二次减数分裂均出现了错误。
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