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Characterization of the endogenous nonecotropic murine leukemia viruses of NZB/B1NJ and SM/J inbred strains.

作者信息

Frankel W N, Lee B K, Stoye J P, Coffin J M, Eicher E M

机构信息

Department of Molecular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.

出版信息

Mamm Genome. 1992;2(2):110-22. doi: 10.1007/BF00353859.

DOI:10.1007/BF00353859
PMID:1311971
Abstract

We characterized 84 endogenous nonecotropic proviruses of NZB/B1NJ and SM/J inbred strains by examining proviral junction fragment segregation in recombinant inbred (RI) and backcross mice. Forty-five proviruses were shared with other laboratory strains, but 28 were unique to NZB/B1NJ or SM/J. Proviral loci were located on 17 of the 19 mouse autosomes and on both sex chromosomes. These markers will facilitate gene mapping in the NXSM RI set and contribute to the pursuit of a more complete map of the mouse genome.

摘要

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Analysis of the env gene of a molecularly cloned and biologically active Moloney mink cell focus-forming proviral DNA.对分子克隆且具有生物活性的莫洛尼貂细胞病灶形成前病毒DNA的env基因进行分析。
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Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse.水貂细胞病灶诱导和嗜异性env基因家族在小鼠中的染色体定位。
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Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal regions encoding mouse lymphocyte antigens.
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Sgp3 and TLR7 stimulation differentially alter the expression profile of modified polytropic retroviruses implicated in murine systemic lupus.Sgp3 和 TLR7 刺激可改变参与小鼠系统性红斑狼疮的修饰多嗜性逆转录病毒的表达谱。
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Sgp3 and Sgp4 control expression of distinct and restricted sets of xenotropic retroviruses encoding serum gp70 implicated in murine lupus nephritis.Sgp3 和 Sgp4 控制表达不同且受限的一组嗜异性逆转录病毒，这些病毒编码与小鼠狼疮肾炎有关的血清 gp70。
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The Sgp3 locus derived from the 129 strain is responsible for enhanced endogenous retroviral expression in macroH2A1-deficient mice.Sgp3 基因座来源于 129 品系，负责增强宏染色体结构维持蛋白 1 缺陷型小鼠内源性逆转录病毒的表达。
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