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利用重组近交系小鼠对内源多嗜性前病毒进行基因鉴定。

Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice.

作者信息

Frankel W N, Stoye J P, Taylor B A, Coffin J M

机构信息

Department of Molecular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111.

出版信息

J Virol. 1989 Sep;63(9):3810-21. doi: 10.1128/JVI.63.9.3810-3821.1989.

DOI:10.1128/JVI.63.9.3810-3821.1989
PMID:2547997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250974/
Abstract

Forty-seven endogenous polytropic murine viruses (Pmv) were identified by examination of proviral-cellular DNA junction fragment segregation in recombinant inbred (RI) mice. Most Pmv loci were found in more than one of the seven RI progenitor strains analyzed, but only four were present in all strains. Chromosomal assignments for 41 Pmv loci were determined by comparing their RI strain distribution patterns with those of known genetic markers. Pmv loci were found dispersed throughout the genome, with chromosomes 1, 3, 4, 5, 7, 11, 12, 15, and 16 each carrying three or more proviruses. Linkage analysis in the AKXD RI set suggested that the gene encoding mink cell focus-forming virus resistance (Rcmfr) of DBA/2J mice is probably not a Pmv provirus. It was also deduced that no single, AKR/J-specific Pmv provirus is required as an env gene donor for thymomagenic mink cell focus-forming viruses. In addition, a Pmv provirus was very closely associated with the albino mutation on chromosome 7.

摘要

通过检查重组近交（RI）小鼠中前病毒-细胞DNA连接片段的分离情况，鉴定出了47种内源性多嗜性鼠病毒（Pmv）。在分析的7个RI祖系品系中，大多数Pmv基因座存在于不止一个品系中，但所有品系中仅存在4个。通过将41个Pmv基因座的RI品系分布模式与已知遗传标记的模式进行比较，确定了它们的染色体定位。发现Pmv基因座分散在整个基因组中，1号、3号、4号、5号、7号、11号、12号、15号和16号染色体各携带三种或更多种前病毒。AKXD RI系中的连锁分析表明，DBA/2J小鼠中编码水貂细胞灶形成病毒抗性（Rcmfr）的基因可能不是Pmv前病毒。还推断，致胸腺性水貂细胞灶形成病毒不需要单一的、AKR/J特异性Pmv前病毒作为env基因供体。此外，一个Pmv前病毒与7号染色体上的白化突变密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c0/250974/bc84c06db572/jvirol00076-0269-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c0/250974/5e75c33f2596/jvirol00076-0268-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c0/250974/bc84c06db572/jvirol00076-0269-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c0/250974/5e75c33f2596/jvirol00076-0268-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c0/250974/bc84c06db572/jvirol00076-0269-a.jpg

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