Chen S-Y, Chen C-L, Shen M-L, Kamatani N
Department of Internal Meidcine, Taipei Municipal Ho-Ping Hospital, Taiwan.
Rheumatology (Oxford). 2003 Dec;42(12):1529-33. doi: 10.1093/rheumatology/keg422. Epub 2003 Sep 16.
To elucidate the recent changes in the clinical manifestations, risk factors and disorders associated with gout.
All gouty cases in Ho-Ping Gout Database were divided into two groups according to the date of first visit to our clinic: 1983-1991 (earlier group) and 1992-1999 (later group). Study variables were compared between these two groups.
In the later group, the age at onset of gout was lower by 2.7 yr (P < 0.0001) and the percentages of female gout and familial gout were higher (P = 0.0046 and P < 0.0001, respectively). Joint counts and the percentage of frequency of attacks > or =6 times/yr were lower in the later group (P < 0.0001), while the percentage of tophaceous gout was higher by 0.8% in the later group (P = 0.0004). The percentage of first attack at ankle was higher (P < 0.0001), while those at Achilles tendon, knee and upper extremity were lower in the later group (P < 0.0001). The percentages of diuretic use and alcohol consumption were lower in the later group (P < 0.0001). The percentages of obesity, hypertriglyceridaemia and nephrolithiasis were higher (P < 0.0001), while the percentages of hypertension and hypercholesterolaemia were lower in the later group (P < 0.0001 and P = 0.0003, respectively). The percentages of type 2 diabetes mellitus and renal insufficiency were not significantly different in multivariate analyses.
The age of onset, clinical manifestations, risk factors and disorders associated with gout have recently changed in Taiwan.
阐明痛风的临床表现、危险因素及相关疾病的近期变化。
将和平痛风数据库中的所有痛风病例根据首次就诊日期分为两组：1983 - 1991年（早期组）和1992 - 1999年（后期组）。对这两组的研究变量进行比较。
在后期组中，痛风发病年龄降低了2.7岁（P < 0.0001），女性痛风和家族性痛风的比例更高（分别为P = 0.0046和P < 0.0001）。后期组的关节受累数以及每年发作≥6次的发作频率百分比更低（P < 0.0001），而后期组痛风石性痛风的比例高0.8%（P = 0.0004）。后期组踝关节首次发作的比例更高（P < 0.0001），而跟腱、膝关节和上肢首次发作的比例更低（P < 0.0001）。后期组使用利尿剂和饮酒的比例更低（P < 0.0001）。肥胖、高甘油三酯血症和肾结石的比例更高（P < 0.0001），而后期组高血压和高胆固醇血症的比例更低（分别为P < 0.0001和P = 0.0003）。在多因素分析中，2型糖尿病和肾功能不全的比例无显著差异。
台湾地区痛风的发病年龄、临床表现、危险因素及相关疾病最近发生了变化。
