Eliasson K, Ryttig K R, Hylander B, Rössner S
Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden.
J Hypertens. 1992 Feb;10(2):195-9. doi: 10.1097/00004872-199202000-00014.
To study the effects of a dietary fibre supplement given as monotherapy upon blood pressure in mildly hypertensive patients.
The investigation was performed as a prospective randomized, double-blind, placebo-controlled trial for 3 months.
Patients attending an outpatient hypertension clinic in a hospital.
Hypertensive patients with a minimum of two diastolic blood pressure (DBP) readings greater than 90 mmHg during a 2-week run-in period were included. Of the 65 patients enrolled, 63 were randomized (32 fibre, 31 placebo). Six patients did not complete the trial.
Patients were treated with either fibre (7 g/day) or matching placebo.
Based on previous studies, the a priori hypothesis was that dietary fibre supplementation could reduce blood pressure in hypertensive patients.
Body weight was significantly reduced in the fibre group. Dietary fibre significantly reduced DBP and fasting serum insulin. However, no correlation between changes in body weight and systolic blood pressure or DBP was found.
A dietary fibre supplement can lower DBP in mildly hypertensive patients independent of changes in body weight.
研究膳食纤维补充剂单药治疗对轻度高血压患者血压的影响。
该研究为前瞻性随机双盲安慰剂对照试验，为期3个月。
一家医院的门诊高血压诊所。
纳入在2周导入期内至少有两次舒张压（DBP）读数大于90 mmHg的高血压患者。在登记的65名患者中，63名被随机分组（32名服用纤维，31名服用安慰剂）。6名患者未完成试验。
患者接受纤维（7克/天）或匹配的安慰剂治疗。
基于先前的研究，先验假设是补充膳食纤维可降低高血压患者的血压。
纤维组体重显著降低。膳食纤维显著降低了舒张压和空腹血清胰岛素。然而，未发现体重变化与收缩压或舒张压之间存在相关性。
膳食纤维补充剂可降低轻度高血压患者的舒张压，且与体重变化无关。
