Rigaud D, Ryttig K R, Angel L A, Apfelbaum M
Nutrition Dept, CHU Bichat, Paris, France.
Int J Obes. 1990 Sep;14(9):763-9.
Fifty-two (41 females, 11 males) overweight patients, mean body mass index (BMI) = 29.3, were treated for 6 months in a randomized, double-blind, placebo-controlled, parallel group design. The treatment consisted of an energy restricted diet and a dietary fibre supplement amounting to 7 g/day. After treatment the weight reduction in the fibre-treated group, 5.5 +/- 0.7 kg, was significantly higher than that of the placebo group, 3.0 +/- 0.5 kg (P = 0.005). Both groups were normotensive and comparable commencing treatment, 126.5/75.6 +/- 2.0/1.3 mm Hg versus 126.7/78.7 +/- 2.5/1.6 mm Hg. The treatment changed blood pressure non-significantly. Hunger feelings using visual analogue scales (VAS) were significantly reduced from 139.8 +/- 8.2 cm to 118.3 +/- 7.0 cm in the fibre-treated group, whereas a significant increase from 129.5 +/- 6.9 cm to 146.9 +/- 8.8 cm (P less than 0.02) was seen in the placebo group. Side-effects were predominantly gastrointestinal and equally distributed in the two groups. It is concluded that a dietary fibre supplement is of value in the management of overweight, enhancing weight loss and decreasing hunger feelings.
52名超重患者（41名女性，11名男性），平均体重指数（BMI）为29.3，采用随机、双盲、安慰剂对照、平行组设计进行了6个月的治疗。治疗包括能量限制饮食和每天7克的膳食纤维补充剂。治疗后，纤维治疗组体重减轻5.5±0.7千克，显著高于安慰剂组的3.0±0.5千克（P = 0.005）。两组在开始治疗时血压正常且具有可比性，分别为126.5/75.6±2.0/1.3毫米汞柱和126.7/78.7±2.5/1.6毫米汞柱。治疗对血压的改变不显著。使用视觉模拟量表（VAS）测量的饥饿感在纤维治疗组中从139.8±8.2厘米显著降低至118.3±7.0厘米，而在安慰剂组中则从129.5±6.9厘米显著增加至146.9±8.8厘米（P＜0.02）。副作用主要是胃肠道方面的，且在两组中分布均匀。结论是，膳食纤维补充剂在超重管理中具有价值，可促进体重减轻并减少饥饿感。
