Hammar S P, Luu J Y, Bockus D E, Remington F L, Luu J W, Friedman S, Bean M A
Diagnostic Specialties Laboratory, Bremerton, Washington 98310.
Ultrastruct Pathol. 1992 Jan-Apr;16(1-2):211-8. doi: 10.3109/01913129209074562.
Tubuloreticular structures were induced in human umbilical vein endothelial cells cultured in media containing recombinant interferon alfa and beta but not in media containing recombinant interferon gamma or other agents that induce interferon, such as 5-bromodeoxyuridine or polyinosinicpolycytidylic acid. Recombinant interferon beta induced tubuloreticular structures in endothelial cells at a lower concentration and in a greater percentage of cell sections than recombinant interferon alfa. This report of tubuloreticular structures being induced in vitro in nonlymphoid cells provides evidence that interferon is the substance that causes the formation of tubuloreticular structures in endothelial cells in vivo.
在含有重组干扰素α和β的培养基中培养的人脐静脉内皮细胞中可诱导出管网状结构，但在含有重组干扰素γ或其他诱导干扰素的试剂（如5-溴脱氧尿苷或聚肌苷酸-聚胞苷酸）的培养基中则不会出现。与重组干扰素α相比，重组干扰素β在较低浓度和更大比例的细胞切片中可诱导内皮细胞形成管网状结构。这一关于在非淋巴细胞中体外诱导出管网状结构的报告提供了证据，表明干扰素是体内导致内皮细胞中管网状结构形成的物质。
