Spinillo A, Tenti P, Zappatore R, Barbarini G, Maccabruni A, Carratta L, Guaschino S
Department of Obstetrics & Gynaecology, University of Pavia, IRCCS Policlinico, Italy.
Eur J Obstet Gynecol Reprod Biol. 1992 Feb 28;43(3):235-41. doi: 10.1016/0028-2243(92)90179-3.
The prevalence of lower genital neoplasia and Human Papilloma-virus-related genital lesions were evaluated in a cohort of 75 women with Human Immunodeficiency Virus type 1 (HIV-1) infection at different stages of HIV disease. The overall rate of cervical intraepithelial neoplasia (CIN) in the group studied was 29.3% (22/75). Eight out of 10 high-grade CIN lesions contained 'high-risk' HPV-DNA 16/18 and/or 31/35/51 as demonstrated by 'in situ' hybridization with biotinylated probes. Vulvar and/or perianal condylomata were histologically diagnosed in 14 patients (18.7%); nine of these biopsies contained detectable HPV-DNA which was always related to HPV 6/11. The rate of high-grade CIN in symptomatic HIV-infected patients was 28% (7/25) as compared to 6% (3/50) of the other cases (P = 0.022). CD4 lymphocyte counts, white blood cell counts, CD4+/CD8+ cell ratio and percentage of CD4+ lymphocytes were lower in patients with high-grade CIN in comparison to the patients with negative colposcopical and/or cytological examination. After adequate standard treatment (cryotherapy, electrocauterization, cold-knife conization) only one case of CIN 2 recurred during the 2 years of follow-up period. The prevalence of lower genital neoplasia and HPV-related lesions among HIV-infected women is high and seems to correlate with the severity of HIV disease.
在一组75名处于人类免疫缺陷病毒1型（HIV-1）感染不同阶段的女性中，评估了下生殖道肿瘤及人乳头瘤病毒相关的生殖器病变的患病率。在所研究的组中，宫颈上皮内瘤变（CIN）的总体发生率为29.3%（22/75）。通过生物素化探针原位杂交显示，10例高级别CIN病变中有8例含有“高危”HPV-DNA 16/18和/或31/35/51。14例患者（18.7%）经组织学诊断为外阴和/或肛周湿疣；其中9例活检标本含有可检测到的HPV-DNA，且均与HPV 6/11相关。有症状的HIV感染患者中高级别CIN的发生率为28%（7/25），而其他病例为6%（3/50）（P = 0.022）。与阴道镜和/或细胞学检查阴性的患者相比，高级别CIN患者的CD4淋巴细胞计数、白细胞计数、CD4+/CD8+细胞比值及CD4+淋巴细胞百分比更低。经过适当的标准治疗（冷冻疗法、电灼术、冷刀锥切术）后，在2年的随访期内仅1例CIN 2复发。HIV感染女性中下生殖道肿瘤及HPV相关病变的患病率较高，且似乎与HIV疾病的严重程度相关。
