对患有和未患有病变的日本女性子宫颈脱落细胞中人乳头瘤病毒6/11型、16型和18型的检测。
Detection of human papillomavirus types 6/11, 16 and 18 in exfoliated cells from the uterine cervices of Japanese women with and without lesions.
作者信息
Yokota H, Yoshikawa H, Shiromizu K, Kawana T, Mizuno M
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo.
出版信息
Jpn J Cancer Res. 1990 Sep;81(9):896-901. doi: 10.1111/j.1349-7006.1990.tb02664.x.
Human papillomavirus (HPV) infection of the uterine cervices of Japanese women with and without lesions was identified by the filter in situ hybridization method. Exfoliated cervical cells from 23 cervical papillary condylomas, 70 cervical intraepithelial neoplasia (CIN) grade I/II, 26 CIN III, 31 invasive cervical cancers and 666 cervices without evidence of disease (including 53 pregnant women) were tested for the presence of HPV types 6/11, 16 and 18. The positive rates for the detection of HPV types 6/11, 16 and 18 DNA were 47.8%, 26.1% and 8.7% in cervical condylomas, 5.7%, 15.7% and 8.6% in CIN I/II, 0, 34.6% and 0 in CIN III, 3.2%, 38.7% and 9.7% in invasive cervical cancers and 0.9%, 1.8% and 0.6% in the control cervices. These data suggest that, in Japan, HPV6/11, HPV16 and HPV18 infections are also prevalent in cervical cells with normal phenotype, and the type of HPV infection of the uterine cervix is related to the histological diagnosis.
采用滤膜原位杂交法对有病变和无病变的日本女性子宫颈进行人乳头瘤病毒（HPV）感染检测。对来自23例宫颈乳头状湿疣、70例I/II级宫颈上皮内瘤变（CIN）、26例CIN III级、31例浸润性宫颈癌以及666例无病变证据的子宫颈（包括53例孕妇）的脱落宫颈细胞检测HPV 6/11型、16型和18型。HPV 6/11型、16型和18型DNA的检测阳性率在宫颈湿疣中分别为47.8%、26.1%和8.7%，在CIN I/II中分别为5.7%、15.7%和8.6%，在CIN III中分别为0、34.6%和0，在浸润性宫颈癌中分别为3.2%、38.7%和9.7%，在对照子宫颈中分别为0.9%、1.8%和0.6%。这些数据表明，在日本，HPV6/11、HPV16和HPV18感染在具有正常表型的宫颈细胞中也很普遍，子宫颈HPV感染类型与组织学诊断有关。
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