Mahalingam R, Clarke P, Wellish M, Dueland A N, Soike K F, Gilden D H, Cohrs R
Department of Neurology, University of Colorado School of Medicine, Denver 80262.
Virology. 1992 May;188(1):193-7. doi: 10.1016/0042-6822(92)90749-f.
We used polymerase chain reaction to analyze the prevalence and distribution of latent simian varicella virus (SVV) in ganglionic and nonganglionic tissues from nine African green monkeys experimentally infected with SVV. Primers specific for three different regions of the SVV genome were used for amplification. SVV DNA sequences were detected in trigeminal ganglia from seven of nine monkeys and in thoracic ganglia from seven of nine monkeys. Analysis of DNA from nonneuronal tissues of three monkeys and from adrenal glands of nine monkeys revealed the presence of SVV-specific sequences in the adrenal gland of one monkey. The results indicate that, like human varicella, SVV becomes latent primarily in ganglia at multiple levels of the neuraxis, and more than one region of the SVV genome is present in latently infected ganglia. SVV latency in primates may be a useful model for varicella latency in humans.
我们利用聚合酶链反应分析了9只经实验感染猿猴水痘病毒（SVV）的非洲绿猴神经节和非神经节组织中潜伏性SVV的流行情况和分布。使用针对SVV基因组三个不同区域的特异性引物进行扩增。在9只猴子中的7只的三叉神经节以及9只猴子中的7只的胸神经节中检测到了SVV DNA序列。对3只猴子的非神经组织和9只猴子的肾上腺的DNA分析显示，其中1只猴子的肾上腺中存在SVV特异性序列。结果表明，与人类水痘一样，SVV主要在神经轴多个水平的神经节中潜伏，并且潜伏感染的神经节中存在不止一个SVV基因组区域。灵长类动物中的SVV潜伏可能是人类水痘潜伏的有用模型。
