α2干扰素结合的糖脂修饰。α2干扰素受体与维罗毒素（志贺样毒素）B亚基之间的序列相似性。
Glycolipid modification of alpha 2 interferon binding. Sequence similarity between the alpha 2 interferon receptor and verotoxin (Shiga-like toxin) B-subunit.
作者信息
Lingwood C A, Yiu S K
机构信息
Department of Microbiology, Hospital for Sick Children, Toronto, Ontario, Canada.
出版信息
Biochem J. 1992 Apr 1;283 ( Pt 1)(Pt 1):25-6. doi: 10.1042/bj2830025.
Previous studies have implicated the glycolipid receptor for the Escherichia coli-derived verotoxin, globotriaosylceramide (Gb3; Gal alpha 1-4Gal beta 1-4Glc-ceramide), in the mechanism of alpha 2 interferon signal transduction. Comparison of the amino acid sequence of the human alpha 2 interferon receptor with that of the B (receptor-binding)-subunit of verotoxin shows three regions of similarity which may provide a structural basis for alpha 2-interferon-receptor/Gb3 interaction.
先前的研究表明，大肠杆菌源维罗毒素的糖脂受体，即球三糖神经酰胺（Gb3；Galα1-4Galβ1-4Glc-神经酰胺），参与了α2干扰素信号转导机制。将人α2干扰素受体的氨基酸序列与维罗毒素的B（受体结合）亚基的氨基酸序列进行比较，发现有三个相似区域，这可能为α2干扰素受体/Gb3相互作用提供结构基础。
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