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米诺地尔能特异性降低培养的人皮肤成纤维细胞中赖氨酸羟化酶的表达。

Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts.

作者信息

Hautala T, Heikkinen J, Kivirikko K I, Myllylä R

机构信息

Collagen Research Unit, University of Oulu, Finland.

出版信息

Biochem J. 1992 Apr 1;283 ( Pt 1)(Pt 1):51-4. doi: 10.1042/bj2830051.

DOI:10.1042/bj2830051
PMID:1314568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1130991/
Abstract

The levels of lysine hydroxylase protein and the levels of the mRNAs for lysine hydroxylase and the alpha- and beta-subunits of proline 4-hydroxylase were measured in cultured human skin fibroblasts treated with 1 mM-minoxidil. The data demonstrate that minoxidil decreases the amount of lysine hydroxylase protein, this being due to a decrease in the level of lysine hydroxylase mRNA. The effect of minoxidil appears to be highly specific, as no changes were observed in the amounts of mRNAs for the alpha- and beta-subunits of proline 4-hydroxylase.

摘要

在用1 mM米诺地尔处理的培养人皮肤成纤维细胞中，检测了赖氨酸羟化酶蛋白水平以及赖氨酸羟化酶和脯氨酸4-羟化酶α和β亚基的mRNA水平。数据表明，米诺地尔减少了赖氨酸羟化酶蛋白的量，这是由于赖氨酸羟化酶mRNA水平的降低。米诺地尔的作用似乎具有高度特异性，因为脯氨酸4-羟化酶α和β亚基的mRNA量未观察到变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46f6/1130991/a30c100fe40a/biochemj00138-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46f6/1130991/d6e13fd603bf/biochemj00138-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46f6/1130991/6edc981c9b69/biochemj00138-0061-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46f6/1130991/a30c100fe40a/biochemj00138-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46f6/1130991/d6e13fd603bf/biochemj00138-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46f6/1130991/6edc981c9b69/biochemj00138-0061-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46f6/1130991/a30c100fe40a/biochemj00138-0062-a.jpg

相似文献

1
Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts.米诺地尔能特异性降低培养的人皮肤成纤维细胞中赖氨酸羟化酶的表达。
Biochem J. 1992 Apr 1;283 ( Pt 1)(Pt 1):51-4. doi: 10.1042/bj2830051.
2
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Effects of minoxidil on human skin fibroblasts in culture.米诺地尔对培养的人皮肤成纤维细胞的影响。
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本文引用的文献

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Human lysyl hydroxylase: purification to homogeneity, partial characterization and comparison of catalytic properties with those of a mutant enzyme from Ehlers-Danlos syndrome type VI fibroblasts.
Coll Relat Res. 1981 Jul;1(4):355-66. doi: 10.1016/s0174-173x(81)80012-x.
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Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol.培养的人皮肤成纤维细胞中I型前胶原mRNA的合成与降解及皮质醇的作用
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Sequence of membrane-associated thyroid hormone binding protein from bovine liver: its identity with protein disulphide isomerase.牛肝膜相关甲状腺激素结合蛋白的序列：其与蛋白质二硫键异构酶的同一性。
了解针对羟赖氨酸醛衍生的胶原交联逆转口腔黏膜下纤维化的分子机制。
J Carcinog. 2021 Aug 13;20:9. doi: 10.4103/jcar.JCar_24_20. eCollection 2021.
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Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-β₁/Smad3 Signaling Pathway.米诺地尔通过抑制赖氨酰羟化酶抑制胶原沉积，通过 TGF-β₁/Smad3 信号通路预防肺纤维化。
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Effects of minoxidil gel on burn wound healing in rats.米诺地尔凝胶对大鼠烧伤创面愈合的影响。
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[Androgenetic alopecia].雄激素性脱发
Hautarzt. 2004 Jan;55(1):89-111; quiz 110-1. doi: 10.1007/s00105-003-0673-4.
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The nucleotide sequence of a human cellular thyroid hormone binding protein present in endoplasmic reticulum.内质网中存在的一种人类细胞甲状腺激素结合蛋白的核苷酸序列。
J Biol Chem. 1987 Aug 15;262(23):11221-7.
5
Polyclonal and monoclonal antibodies to human lysyl hydroxylase and studies on the molecular heterogeneity of the enzyme.针对人赖氨酰羟化酶的多克隆抗体和单克隆抗体以及该酶分子异质性的研究。
Biochem J. 1988 Jul 15;253(2):489-96. doi: 10.1042/bj2530489.
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Recent developments in posttranslational modification: intracellular processing.翻译后修饰的最新进展：细胞内加工
Methods Enzymol. 1987;144:96-114. doi: 10.1016/0076-6879(87)44175-x.
7
Molecular cloning of the beta-subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene.人脯氨酰4-羟化酶β亚基的分子克隆。该亚基与蛋白质二硫键异构酶是同一基因的产物。
EMBO J. 1987 Mar;6(3):643-9. doi: 10.1002/j.1460-2075.1987.tb04803.x.
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A single polypeptide acts both as the beta subunit of prolyl 4-hydroxylase and as a protein disulfide-isomerase.一种单一的多肽既作为脯氨酰 4-羟化酶的β亚基，又作为蛋白质二硫键异构酶发挥作用。
J Biol Chem. 1987 May 15;262(14):6447-9.
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Post-translational processing of procollagens.前胶原的翻译后加工
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Molecular cloning of a multifunctional chicken protein acting as the prolyl 4-hydroxylase beta-subunit, protein disulphide-isomerase and a cellular thyroid-hormone-binding protein. Comparison of cDNA-deduced amino acid sequences with those in other species.一种多功能鸡蛋白的分子克隆，该蛋白可作为脯氨酰4-羟化酶β亚基、蛋白质二硫键异构酶和一种细胞甲状腺激素结合蛋白。将cDNA推导的氨基酸序列与其他物种的序列进行比较。
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