Girardi F, Fuchs P, Haas J
Department of Obstetrics and Gynecology, University of Graz, Austria.
Cancer. 1992 May 15;69(10):2502-4. doi: 10.1002/1097-0142(19920515)69:10<2502::aid-cncr2820691019>3.0.co;2-7.
Human papillomavirus (HPV) type 16 DNA is frequent in invasive cervical cancers. Among 43 patients with invasive cervical cancer, HPV-16-positive tumors spread to the parametrial and pelvic lymph nodes significantly more often than did HPV-16-negative tumors (P less than 0.05). Demonstration of HPV-16 DNA in invasive cervical cancers may be an additional prognostic factor for this disease.