Araújo Jorge Hospital, Goiás Anticancer Association, Goiânia/GO, Brazil.
Clinics (Sao Paulo). 2013 Jun;68(6):809-14. doi: 10.6061/clinics/2013(06)14.
This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis.
A single-center cohort study was conducted with 86 patients who had undergone radical hysterectomy for stage I cervical cancer. Prognostic factors and the presence of HPV 16 and 18 were analyzed using a polymerase chain reaction assay. A univariate analysis using Kaplan-Meier curves was conducted to estimate survival.
The prevalence of HPV 16 in the study group was 65.3%, and the prevalence of HPV 18 was 33.3%. The prevalence of infection with both viruses was 26.9%. Overall survival at 5 years was 91% among women with HPV 18 and 96% among those without this virus type (p=0.133). Among the women with HPV 16, the overall survival was 94%, whereas this rate was 96% among those without this virus type (p=0.663). Disease-free survival was unaffected by the presence of HPV type 16 or 18.
In the present study, despite the high prevalence of HPV types 16 and 18, the presence of these virus types did not affect the prognosis of patients with stage I cervical cancer who underwent radical hysterectomy.
本研究旨在评估接受根治性子宫切除术加盆腔淋巴结清扫术治疗的临床分期 IB 期宫颈癌女性中 HPV 型 16 和 18 的流行率，并确定 HPV 型与癌症预后之间的相关性。
对 86 例接受根治性子宫切除术治疗的 I 期宫颈癌患者进行了单中心队列研究。使用聚合酶链反应检测分析了预后因素和 HPV 16 和 18 的存在情况。采用 Kaplan-Meier 曲线进行单因素分析来估计生存率。
研究组 HPV 16 的流行率为 65.3%，HPV 18 的流行率为 33.3%。两种病毒同时感染的流行率为 26.9%。HPV 18 感染的女性 5 年总生存率为 91%，无该病毒类型的女性为 96%（p=0.133）。HPV 16 感染的女性总生存率为 94%，而无该病毒类型的女性为 96%（p=0.663）。HPV 型 16 或 18 的存在并不影响无病生存率。
在本研究中，尽管 HPV 型 16 和 18 的流行率较高，但这些病毒类型的存在并未影响接受根治性子宫切除术的 I 期宫颈癌患者的预后。
