Atluru D, Gudapaty S, Xue W, Gurria F, Chengappa M M, McVey D S, Minocha H C, Atluru S
Department of Anatomy and Physiology, Kansas State University, Manhattan 66506.
Vet Immunol Immunopathol. 1992 Feb 15;31(1-2):49-59. doi: 10.1016/0165-2427(92)90086-6.
Bovine viral diarrhea (BVD) virus inhibited phytohemagglutinin (PHA)-, PHA plus phorbol-12-myristate-13 acetate (PMA)- or PHA plus calcium ionophore (A23187)-stimulated bovine peripheral blood mononuclear cell (PBMC) proliferation. Further, BVD-virus inhibited A23187-stimulated leukotriene B4 (LTB4) synthesis into the culture supernatants. Presence of exogenous LTB4 failed to reverse the BVD virus-induced immunosuppression. Our results suggest that BVD virus-induced immunosuppression is due to a factor that may be necessary to induce LTB4 synthesis for normal mononuclear cell proliferation.
牛病毒性腹泻（BVD）病毒抑制植物血凝素（PHA）、PHA加佛波醇-12-肉豆蔻酸酯-13-乙酸酯（PMA）或PHA加钙离子载体（A23187）刺激的牛外周血单个核细胞（PBMC）增殖。此外，BVD病毒抑制A23187刺激的白三烯B4（LTB4）合成到培养上清液中。外源性LTB4的存在未能逆转BVD病毒诱导的免疫抑制。我们的结果表明，BVD病毒诱导的免疫抑制是由于一种可能是正常单核细胞增殖诱导LTB4合成所必需的因子。
