Horn H, Erlichman I, Levij I S
Br J Cancer. 1976 Mar;33(3):336-41. doi: 10.1038/bjc.1976.48.
The effect of calusterone (7beta,17alpha-dimethyltestosterone) on rat mammary DMBA-induced adenocarcinoma was studied both in vivo and in organ culture. In vivo all 8 tumours with a diameter of less than 30 mm regressed following calusterone injection (10 mg/day for 2-3 weeks). In organ culture calusterone (20 mug/ml medium) inhibited the synthesis of DNA and RNA in all 7 cases examined. Testosterone also inhibited the synthesis of DNA and RNA in organ culture in 12 out of 14 and 10 out of 14 tumours respectively. Oestradiol-17beta on the other hand had no effect on DNA and RNA synthesis in organ culture although 70% of the tumours examined were ovarian dependent, i.e. regressed following castration. This could be explained by the direct effect of calusterone on rat adenocarcinoma compared with the indirect effect of oestradiol-17beta which probably exerts its action by activating the secretion of prolactin which acts on the tumour.
研究了卡鲁睾酮（7β,17α-二甲基睾酮）对大鼠乳腺二甲基苯并蒽（DMBA）诱导的腺癌在体内和器官培养中的作用。在体内，注射卡鲁睾酮（10毫克/天，持续2至3周）后，所有8个直径小于30毫米的肿瘤均消退。在器官培养中，卡鲁睾酮（20微克/毫升培养基）在所有7例检测病例中均抑制了DNA和RNA的合成。睾酮在器官培养中也分别在14个肿瘤中的12个和14个肿瘤中的10个中抑制了DNA和RNA的合成。另一方面，雌二醇-17β对器官培养中的DNA和RNA合成没有影响，尽管所检测的肿瘤中有70%依赖卵巢，即去势后消退。这可以通过卡鲁睾酮对大鼠腺癌的直接作用来解释，与之相比，雌二醇-17β可能通过激活作用于肿瘤的催乳素分泌来发挥作用，其作用是间接的。
