卡鲁睾酮对二甲基苯并蒽诱导的大鼠乳腺腺癌的体内及器官培养抗肿瘤疗效
Anti-tumour efficacy of calusterone against DMBA-induced rat mammary adenocarcinoma in vivo and in organ culture.
作者信息
Horn H, Erlichman I, Levij I S
出版信息
Br J Cancer. 1976 Mar;33(3):336-41. doi: 10.1038/bjc.1976.48.
The effect of calusterone (7beta,17alpha-dimethyltestosterone) on rat mammary DMBA-induced adenocarcinoma was studied both in vivo and in organ culture. In vivo all 8 tumours with a diameter of less than 30 mm regressed following calusterone injection (10 mg/day for 2-3 weeks). In organ culture calusterone (20 mug/ml medium) inhibited the synthesis of DNA and RNA in all 7 cases examined. Testosterone also inhibited the synthesis of DNA and RNA in organ culture in 12 out of 14 and 10 out of 14 tumours respectively. Oestradiol-17beta on the other hand had no effect on DNA and RNA synthesis in organ culture although 70% of the tumours examined were ovarian dependent, i.e. regressed following castration. This could be explained by the direct effect of calusterone on rat adenocarcinoma compared with the indirect effect of oestradiol-17beta which probably exerts its action by activating the secretion of prolactin which acts on the tumour.
研究了卡鲁睾酮（7β,17α-二甲基睾酮）对大鼠乳腺二甲基苯并蒽（DMBA）诱导的腺癌在体内和器官培养中的作用。在体内，注射卡鲁睾酮（10毫克/天，持续2至3周）后，所有8个直径小于30毫米的肿瘤均消退。在器官培养中，卡鲁睾酮（20微克/毫升培养基）在所有7例检测病例中均抑制了DNA和RNA的合成。睾酮在器官培养中也分别在14个肿瘤中的12个和14个肿瘤中的10个中抑制了DNA和RNA的合成。另一方面，雌二醇-17β对器官培养中的DNA和RNA合成没有影响，尽管所检测的肿瘤中有70%依赖卵巢，即去势后消退。这可以通过卡鲁睾酮对大鼠腺癌的直接作用来解释，与之相比，雌二醇-17β可能通过激活作用于肿瘤的催乳素分泌来发挥作用，其作用是间接的。
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