Duprez D, De Buyzere M, De Backer T, Vercammen J, Brusselmans F, Clement D L
Department of Cardiology and Angiology, University Hospital, Gent, Belgium.
J Hypertens. 1992 Mar;10(3):251-4. doi: 10.1097/00004872-199203000-00008.
The aim of this study was to correlate capillary morphology and erythrocyte velocity to blood pressure in mild-to-moderate essential arterial hypertension.
Ambulatory blood pressure measurement may provide more precise information about a patient's mean blood pressure than office measurements.
Fifteen patients with recently diagnosed, previously untreated mild-to-moderate essential hypertension underwent 24-h ambulatory blood pressure recording and a capillaroscopic examination of finger microcirculation. Erythrocyte velocity was determined by the flying spot technique.
Both mean 24-h ambulatory systolic blood pressure (SBP) and mean 24-h ambulatory diastolic blood pressure (DBP) were significantly inversely correlated with capillary erythrocyte velocity. However, the correlation between erythrocyte velocity and office SBP and office DBP was less significant. Capillary length was related to 24-h ambulatory DBP but not to office DBP. Capillary number was not related to any blood pressure parameter.
These results indicate that, in patients with mild-to-moderate essential hypertension, erythrocyte velocity is significantly lower than for matched controls. It is also inversely related to mean 24-h ambulatory SBP and 24-h ambulatory DBP.
本研究旨在探讨轻度至中度原发性高血压患者的毛细血管形态和红细胞流速与血压之间的关系。
动态血压测量可能比诊室测量能提供更精确的患者平均血压信息。
15例近期诊断、未经治疗的轻度至中度原发性高血压患者接受了24小时动态血压记录及手指微循环的毛细血管镜检查。采用飞点技术测定红细胞流速。
24小时动态收缩压（SBP）均值和24小时动态舒张压（DBP）均值均与毛细血管红细胞流速显著负相关。然而，红细胞流速与诊室SBP和诊室DBP之间的相关性较弱。毛细血管长度与24小时动态DBP相关，但与诊室DBP无关。毛细血管数量与任何血压参数均无关。
这些结果表明，在轻度至中度原发性高血压患者中，红细胞流速显著低于匹配的对照组。它还与24小时动态SBP均值和24小时动态DBP均值呈负相关。
