Bean A J, Hökfelt T
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
Brain Res Mol Brain Res. 1992 Feb;12(4):345-8. doi: 10.1016/0169-328x(92)90138-2.
Reserpine administration has been shown to increase striatal tissue levels of neurotensin with a time course similar to that for striatal dopamine depletion. To determine whether reserpine treatment may increase striatal neurotensin synthesis we have examined striatal neurotensin mRNA levels using in situ hybridization histochemistry. The number of striatal cells expressing neurotensin mRNA was increased 6 h, but not 1 h, after reserpine administration. Thus, the increase in striatal tissue levels of neurotensin after reserpine may be due in part to an increase in peptide synthesis.
已证明给予利血平会使纹状体组织中的神经降压素水平升高，其时间进程与纹状体多巴胺耗竭相似。为了确定利血平治疗是否会增加纹状体神经降压素的合成，我们使用原位杂交组织化学方法检测了纹状体神经降压素mRNA水平。给予利血平后6小时，而非1小时，表达神经降压素mRNA的纹状体细胞数量增加。因此，利血平给药后纹状体组织中神经降压素水平的升高可能部分归因于肽合成的增加。
