Taly A B, Muthane U B
Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Acta Neurol Scand. 1992 Apr;85(4):272-5. doi: 10.1111/j.1600-0404.1992.tb04043.x.
We evaluated, by using electrophysiological techniques, 29 patients with juvenile Parkinson's disease (JP), who had no known causes or clinical signs of neuropathy. Electromyographic evidence of chronic partial denervation with reinnervation was observed in nine patients (34.6%). Abnormalities of motor conduction in the common peroneal nerve were present in four (13.8%), Sural sensory conduction in nine (31.9%) and sympathetic skin response (SSR) in eleven (37.9%) patients. The symptoms of dysautonomia correlated poorly with changes in SSR. These abnormalities were independent of age at onset, duration or severity of the disease and antiparkinsonian drugs used. This study suggests that the peripheral nervous system is involved in JP in more than 50% of patients. The commonly observed symptoms of dysautonomia in Parkinson's disease may have a peripheral origin.
我们采用电生理技术对29例青少年帕金森病（JP）患者进行了评估，这些患者无已知的神经病变病因或临床体征。在9例患者（34.6%）中观察到慢性部分失神经伴再支配的肌电图证据。4例（13.8%）患者腓总神经运动传导异常，9例（31.9%）患者腓肠神经感觉传导异常，11例（37.9%）患者交感皮肤反应（SSR）异常。自主神经功能障碍症状与SSR变化的相关性较差。这些异常与发病年龄、病程、疾病严重程度及所用抗帕金森病药物无关。本研究提示，超过50%的青少年帕金森病患者外周神经系统受累。帕金森病中常见的自主神经功能障碍症状可能源于外周。
