Bergman B, Sullivan M, Sörenson S
Department of Pulmonary Medicine, Renströmska Hospital, Göteborg, Sweden.
Acta Oncol. 1992;31(1):19-28. doi: 10.3109/02841869209088260.
Sixty-two patients with small cell lung cancer, 36-80 years of age, who were receiving chemotherapy during a maximum of one year, were consecutively included in a study of quality of life during treatment. An interim version (C-36) of the EORTC Core Quality of Life Questionnaire (QLQ) was applied for quality of life assessment prior to treatment and every third month during the treatment period. The assessments were related to clinical variables (performance status and tumour response), and compared with results from assessment with the Sickness Impact Profile (SIP). The QLQ was sensitive to differences in clinical status and responded to clinical change over time. In general, the pattern of correlations with SIP lends support to the construct validity of the QLQ. However, some questions arose from the comparison with SIP: QLQ emotional functioning did not change in concordance with SIP, and assessment of social functioning was not optimal prior to treatment. The questionnaire was well accepted by the patients. The EORTC QLQ C-36 constitutes a promising step in the development of a feasible standard instrument for quality of life assessment in cancer clinical trials.
62例年龄在36至80岁之间、正在接受为期最长一年化疗的小细胞肺癌患者被连续纳入一项治疗期间生活质量的研究。在治疗前以及治疗期间每三个月，应用欧洲癌症研究与治疗组织核心生活质量问卷（QLQ）的一个中期版本（C-36）进行生活质量评估。这些评估与临床变量（体能状态和肿瘤反应）相关，并与疾病影响量表（SIP）评估结果进行比较。QLQ对临床状态的差异敏感，且随时间推移对临床变化有反应。总体而言，与SIP的相关性模式支持了QLQ的结构效度。然而，与SIP的比较引发了一些问题：QLQ情绪功能的变化与SIP不一致，且治疗前社会功能的评估并不理想。该问卷被患者广泛接受。欧洲癌症研究与治疗组织QLQ C-36是癌症临床试验中生活质量评估可行标准工具开发过程中很有前景的一步。
